[Darya]
[Yu Long]
[Amir]
[Anh]
[Mais]
[Darya]
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2 место - продано (договор 312) 3 место - продано (договор 313) 4 место - продано (договор 314) 5 место - продано (договор 315) 6 место - продано (договор 316) 7 место - продано (договор 317) Дополнительно по статье: Introduction: The aim of the study was to determine long-term tooth survival after endodontic retreatment and whether the presence of intraradicular posts influences the outcome. Methods: Ninety-five teeth were randomly assigned to surgical or nonsurgical endodontic retreatment. Forty-seven teeth in 45 patients were treated by conventional endodontic surgery and 48 teeth (47 patients) by nonsurgical retreatment, including the removal of intraradicular posts in 37 (77%). The outcome was tooth survival; follow-up continued until the tooth had been extracted, at least 10 years had elapsed since retreatment, the patient declined further follow-up, or the patient died. The Fisher exact test was used to analyze differences between the groups. Results: The median follow-up time was 10.1 years (range, 0.0?15.6 years). The overall survival rate was 76%, with no significant differences in long-term tooth survival between retreatment methods or the presence of an intraradicular post. The reasons for tooth extraction were related to the retreatment method. Vertical root fractures were significantly more frequent in the nonsurgical group when retreatment included post removal (P =.036). Conclusions: There was no significant difference in long-term tooth survival after surgical or nonsurgical retreatment. The presence of intraradicular posts did not affect long-term tooth survival, but for teeth with posts, those retreated nonsurgically were more frequently extracted because of vertical root fractures than those retreated surgically (P =.036). The major limitations of the study were a smaller sample size and the use of outmoded retreatment techniques. Ключевые слова: Endodontic retreatment; long-term tooth survival; posts Заказать публикацию № 31 Номер заказа № 31 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 322) 3 место - продано (договор 323) 4 место - продано (договор 324) 5 место - продано (договор 325) 6 место - продано (договор 326) Дополнительно по статье: Inhibitory control is the stopping of a mental process with or without intention, conceptualized as mental suppression of competing information because of limited cognitive capacity. Inhibitory control dysfunction is a core characteristic of many major psychiatric disorders. Inhibition is generally thought to involve the prefrontal cortex; however, a single inhibitory mechanism is insufficient for interpreting the heterogeneous nature of human cognition. It remains unclear whether different dimensions of inhibitory processes?specifically cognitive inhibition, response inhibition, and emotional interference?rely on dissociated neural systems. We conducted systematic meta-analyses of fMRI studies in the BrainMap database supplemented by PubMed using whole-brain activation likelihood estimation. A total of 66 study experiments including 1,447 participants and 987 foci revealed that while the left anterior insula was concordant in all inhibitory dimensions, cognitive inhibition reliably activated specific dorsal frontal inhibitory system, engaging dorsal anterior cingulate, dorsolateral prefrontal cortex, and parietal areas, whereas emotional interference reliably implicated a ventral inhibitory system, involving the ventral surface of the inferior frontal gyrus and the amygdala. Response inhibition showed concordant clusters in the fronto-striatal system, including the dorsal anterior cingulate region and extended supplementary motor areas, the dorsal and ventral lateral prefrontal cortex, basal ganglia, midbrain regions, and parietal regions. We provide an empirically derived dimensional model of inhibition characterizing neural systems underlying different aspects of inhibitory mechanisms. This study offers a fundamental framework to advance current understanding of inhibition and provides new insights for future clinical research into disorders with different types of inhibition-related dysfunctions. Ключевые слова: cognitive control; emotional interference; executive function; inhibition; response inhibition Заказать публикацию № 32 Номер заказа № 32 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 332) 3 место - продано (договор 333) Дополнительно по статье: Although objects around us vary in a number of continuous dimensions (color, size, orientation, etc.), we tend to perceive the objects using more discrete, categorical descriptions (e.g., berries and leaves). Previously, we described how continuous ensemble statistics of simple features are transformed into categorical classes: The visual system tests whether the feature distribution has one or several peaks, each representing a likely ?category?. Here, we tested the mechanism of segmentation for more complex conjunctions of features. Observers discriminated between two textures filled with lines of various lengths and orientations, which had same distributions between the textures, but opposite directions of correlations. Critically, feature distributions could be ?segmentable? (only extreme feature values and a large gap between them) or ?non-segmentable? (both extreme and middle values with smooth transition are present). Segmentable displays yielded steeper psychometric functions indicating better discrimination (Experiment 1). The effect of segmentability arises early in visual processing (Experiment 2) and is likely to be provided by global sampling of the entire field (Experiment 3). Also, rapid segmentation requires both feature dimensions having a ?segmentable? distribution supporting division of the textures into categorical classes of conjunctions. We propose that observers select items from one side (peak) of one dimension and sample mean differences along a second dimension within the selected subset. In this scenario, subset selection is a limiting factor (Experiment 4) of texture discrimination. Yet, segmentability provided by the sharp feature distributions seems to facilitate both subset selection and mean comparison. Ключевые слова: Categorization; Ensemble summary statistics; Features and conjunctions; Sampling; Segmentation; Texture discrimination Заказать публикацию № 33 Номер заказа № 33 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 342) 3 место - продано (договор 343) 4 место - продано (договор 344) 5 место - продано (договор 345) 6 место - продано (договор 346) 7 место - продано (договор 347) Дополнительно по статье: Type 2 diabetes is one of the most common noncommunicable diseases worldwide. The quality of life of people with this metabolic disorder is highly related to nutrition, given that products for glycemic control are of great importance for them. In this study, we have developed marmalades for glycemic control with the aims to investigate the most important sensory characteristics, to study the impact of the sensory properties on the acceptability of these marmalades, and to evaluate a difference in the acceptability of the marmalade samples between healthy people and people with type 2 diabetes. The main objects of the investigation were agar-, gelatin-, and pectin-based marmalades with maltitol, dried fruits, and berries for glycemic control. By means of descriptive sensory analysis, we have shown that major factors of the sensory differentiation of marmalade samples are the type of gelling agent and presence of nonsoluble components such as apple puree, which influencing the perception of ?off-flavor,? ?gumminess,? and ?springiness? sensory attributes. Results of this research show that even with significant differences in sensory attributes it is possible to develop marmalade for glycemic control that will have no differences in the total liking score for the perception of both healthy people and patients with type 2 diabetes. Ключевые слова: acceptance; food quality; pectins; Sensory analysis; sugars Заказать публикацию № 34 Номер заказа № 34 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 352) 3 место - продано (договор 353) 4 место - продано (договор 354) 5 место - продано (договор 355) Дополнительно по статье: Data collected in the European Cystic Fibrosis Society Patient Registry (ECFSPR) database were used to investigate whether risk factors for death in childhood and adolescents CF patients have different impact in countries of different income. In this way, it is possible to recognize where interventions could improve the quality of care and survival in these patients. We matched deceased and alive patients by age, country, year of follow-up. Multivariable logistic models were developed. In the years of this study, the ECFSPR collected information on 24,416 patients younger than 18 years: 7830 patients were from countries with low/middle income and 16,586 from countries with high income; among these the dead are 102 and 107 (p 0.001), respectively. The use of oxygen, forced expiratory volume in one second (FEV1) below 40% and BMI standard deviation score (SDS) below 2 represent risk factors for death. However, some patients from countries with high income remain alive even if their values of FEV1% and BMI-SDS were low, and some deceased patients from countries with high income had high values of FEV1% (60%). Evaluation of mortality in pediatric age may reflect the availability of resources for CF diagnosis and treatment in some countries. Ключевые слова: Childhood; Cystic fibrosis; Lung disease; Mortality; Registry Заказать публикацию № 35 Номер заказа № 35 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 362) 3 место - продано (договор 363) 4 место - продано (договор 364) 5 место - продано (договор 365) 6 место - продано (договор 366) Дополнительно по статье: Objective: To determine the time needed to remotely perform a set of intraoperative measurements during cochlear implantation surgery and to compare it to the time needed to perform the same measurements in theatre. Design: Prospective two-arm study comparing a local with a remote measurement setting. Three intraoperative measurements (Impedance Field Telemetry (IFT), evoked compound action potential (ECAP) and evoked stapedius reflex test (eSRT)) were performed with the audiologist present in the operating theatre (i.e. locally) or with the audiologist in his/her office (i.e. remotely). The time needed to complete the measurements, in total and individually, were measured and compared. Study sample: Fifty cochlear implant recipients, aged 0.7?48 years Results: IFT, ECAP and eSRT were performed successfully in all participants. Comparing locally and remotely performed measurements, IFT did not differ significantly, ECAP threshold or slope did not differ significantly differ in any single channel and eSRT measurements did not differ significantly except for in one of six channels. Remote measurements took 8.6 min less to perform than did local measurements (10.04 vs. 18.64 min); a significant difference (p 0.001). Conclusions: Using a remote network connection for intraoperative objective measurements is an efficient and safe way to perform measurements during cochlear implantation surgery. Ключевые слова: Remote care; remote fitting; telehealth; telemedicine Заказать публикацию № 36 Номер заказа № 36 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 372) 3 место - продано (договор 373) 4 место - продано (договор 374) 5 место - продано (договор 375) 6 место - продано (договор 376) 7 место - продано (договор 377) Дополнительно по статье: OBJECTIVES: The type of conduit used for right ventricular outflow tract (RVOT) reconstruction during the Ross procedure remains problematic because of the limited availability of pulmonary allografts and the unsatisfactory long-term results associated with the use of xenografts. Polytetrafluoroethylene (PTFE) conduits have been proposed as an alternative. This study evaluated the results of RVOT reconstruction using a PTFE conduit during the Ross procedure. METHODS: Between 2007 and 2015, 28 patients underwent RVOT reconstruction using PTFE conduits. The mean age of the patients was 35.9 ? 18.1 (range 4-58) years. The total root replacement technique was used in all patients. The mean PTFE conduit size was 25.3 ? 2.3 mm. RESULTS: The early mortality rate was 3.6% (1 patient). The mean follow-up duration was 48.5 ? 31.2 months; there were no late deaths. The transprosthetic gradients increased significantly over time. The conduit size was the only independent predictor of peak RVOT gradient progression (P = 0.02). None of the patients demonstrated significant RVOT regurgitation. One patient required an RVOT reoperation. CONCLUSIONS: The PTFE conduit demonstrates acceptable haemodynamic results at the mid-term follow-up and could be considered as an alternative substitute for RVOT reconstruction during the Ross procedure. Ключевые слова: Polytetrafluoroethylene conduits; Right ventricular outflow tract reconstruction; Ross operation Заказать публикацию № 37 Номер заказа № 37 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 382) 3 место - продано (договор 383) 4 место - продано (договор 384) 5 место - продано (договор 385) 6 место - продано (договор 386) Дополнительно по статье: Objectives: Creating multi-tooth sequences of micro-sampled stable isotope (SI) analytical data can help track 20+ years of individual dietary history. Inferences about individual and population level behavioral patterns require cross-calibration of the timing of dietary changes recorded by each tooth. Dentin sections from contemporaneous tissues (eg, in M1 and M2) reflect dietary signature for the time of growth. Contemporary sections should produce similar values, allowing alignment of temporally overlapping portions of teeth into multi-tooth sequences. Published methods for determining the ages of incremental sections do not provide guidance for adjustment when poor alignment between individual tooth sequences is encountered. The primary objective is to address this problem; examine cause(s), assess the effects of the standard growth-model on available age-assessment techniques, and provide a viable solution. Methods: Investigating difficulty in aligning a 3-molar sequence at Shamanka II, an Early Neolithic (7000-5700 BP) Kitoi hunter-gatherer cemetery in Cis-Baikal, Siberia, we employed 10 age assessment models and 13 variants of 2 published growth rate methods on 3 individuals of different age and sex. Results: At Shamanka II, dentin initiation and/or growth rates were different from the mostly European, reference populations used to create published age-estimation/growth rate models. Initiation ages for M2 and M3 were delayed. Root formation rates were on the rapid end of known development parameters. Conclusions: Age-assessment methods customized to dentin initiation ages and growth parameters of Siberian populations produced a hybrid growth rate model for dentin section ages and improved alignment for multi-tooth SI sequences over published models. Заказать публикацию № 38 Номер заказа № 38 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 392) 3 место - продано (договор 393) 4 место - продано (договор 394) 5 место - продано (договор 395) 6 место - продано (договор 396) Заказать публикацию № 39 Номер заказа № 39 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 402) 3 место - продано (договор 403) 4 место - продано (договор 404) 5 место - продано (договор 405) 6 место - продано (договор 406) 7 место - продано (договор 407) Дополнительно по статье: In this study, the modified adaptability of the arches of the feet to the load perception in children with a unilateral shortening of the lower limb in the lesion of the proximal femur due to acute hematogenous osteomyelitis was shown. The obtained results of support ability of each of the feet indicate a decrease in the functional capacity of both shortened and unaffected side. Ключевые слова: Children; Foot; Lower limb; Osteomyelitis; Plantography Заказать публикацию № 40 Номер заказа № 40 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 412) 3 место - продано (договор 413) 4 место - продано (договор 414) 5 место - продано (договор 415) Дополнительно по статье: Purpose: The aim of this study was to distinguish different forms of orbital involvement in granulomatosis with polyangiitis (GPA) and to compare their clinical course and outcomes. Methods: Two hundred twenty-six consecutive patients with GPA were retrospectively studied. All patients fulfilled the classification criteria of American College of Rheumatology; diagnosis of localized GPA was established according to Chapel Hill Consensus. Of those, 74 patients with orbital disease were enrolled into further investigation of different forms of orbital disease. Results: Overall ocular involvement was diagnosed in 50% (113/226) of patients; in 5.3% (12/226), inflammatory eye disease resulted in permanent visual loss. Most common ophthalmic manifestations were orbital masses, episcleritis/conjunctivitis, and scleritis (74/226, 32/226, and 12/226, respectively). Seventy-four patients with orbital involvement were divided into three groups: those with orbital mass without primary lacrimal gland involvement (1st group, 45 patients), those with lacrimal gland involvement (2nd group, 26 patients), and those with extraocular myositis (3rd group, 3 patients). Symptoms such as orbital pain, decreased vision, double vision, red eye, scleritis, orbital wall destruction, primary gaze strabismus, and ocular motility restriction were significantly more common in the 1st group. Peripheral ulcerative keratitis (PUK) was present in the 1st group only. Patients of the 1st group suffered from visual loss, double vision, primary gaze strabismus, and ocular motility restriction significantly more often. Eleven of them developed visual loss; 5 of them underwent enucleation, whereas in the group of patients with dacryoadenitis, only 1 patient had BCVA less than 0.3. Conclusions: Three types of orbital disease in GPA were proposed: orbital mass without primary lacrimal gland involvement, dacryoadenitis, and extraocular myositis. Patients with orbital mass without lacrimal gland involvement are characterized with a higher rate of systemic disease, severe clinical course not uncommonly associated with other ophthalmic manifestations (necrotizing scleritis, PUK, orbital walls destruction), relatively unfavorable outcome with high level of morbidity (optic nerve atrophy, anophthalmos, strabismus), and higher rate of recurrences. Dacryoadenitis in GPA showed to be not severe manifestation with favorable prognosis. Ключевые слова: Dacryoadenitis; Granulomatosis with polyangiitis; Myositis; Ophthalmic manifestations; Orbital mass Заказать публикацию № 41 Номер заказа № 41 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 422) 3 место - продано (договор 423) 4 место - продано (договор 424) 5 место - продано (договор 425) Заказать публикацию № 42 Номер заказа № 42 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 432) 3 место - продано (договор 433) Дополнительно по статье: Rationale: Cannabis use impairs visual attention; however, it is unclear whether cannabis use also impairs low level visual processing or whether low level visual deficits can be related to lower dopaminergic functioning found in cannabis users. Objectives: To investigate whether spatiotemporal contrast sensitivity and motion discrimination under normal and low luminance conditions differ in cannabis users and non-users. Methods: Control (n = 20) and cannabis (n = 21) participants completed a visual acuity test, a saliva test and self-report measures. Spatial and temporal contrast thresholds, motion coherence thresholds for translational and radial motion and the spontaneous eye blink rate were then collected. Results: Cannabis users showed decreased spatial contrast sensitivity under low luminance conditions and increased motion coherence thresholds under all luminance levels tested compared to non-users. No differences in temporal contrast sensitivity were found between the groups. Frequency of cannabis use correlated significantly and negatively with contrast sensitivity, both spatial and temporal, in the cannabis group and higher motion coherence thresholds for radial motion were also associated with more frequent cannabis use in this group. The eye blink rate was significantly lower in cannabis users compared to non-users. Conclusions: The present study shows that cannabis use is associated with deficits in low level visual processing. Such deficits are suggested to relate to lower dopamine, in a similar manner as in clinical populations. The implications for driving safety under reduced visibility (e.g. night) in abstaining cannabis users are discussed. Ключевые слова: Cannabis use; Contrast sensitivity; Low luminance; Radial motion; Spontaneous Eye Blink Rate (SEBR); Translational motion Заказать публикацию № 43 Номер заказа № 43 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 442) 3 место - продано (договор 443) 4 место - продано (договор 444) 5 место - продано (договор 445) 6 место - продано (договор 446) Дополнительно по статье: This study examined the trajectories of elite swimmers? recovery-stress states and cardiac vagal-related markers during a 3-month training period preceding the national championship and their within-person relationships with perceived control. A Multilevel Growth Curve Analysis (MGCA) approach was used with 21 male elite swimmers. Four waves of assessments of psychological (stress, recovery, perceived control) and physiological (heart rate recovery, heart rate variability) markers were completed during a 3month training preparation leading to a major competition. Results of MGCA revealed (a) a significant positive linear effect of time (ie, linear increase over time) and a significant negative quadratic effect of time (ie, inverted U shape over time) on perceived stress whereas the opposite pattern of results was observed for perceived recovery; and (b) a significant positive linear effect of time for nHRR60. Both at level 1 (within-person level of analysis) and 2 (between-person level of analysis), perceived control was (a) positively associated with athletes? perceived recovery and parasympathetic markers (ie, MeanRR; pNN50); and (b) negatively related to swimmers? perceived stress. Results also indicated that within-person interactions of perceived control with time reached significance for general recovery and HRV. Finally, within-person interaction of perceived control with squared time reached significance for subjective sport-specific and total stress. Overall, this study provided insights into the key role played by perceived control on both psychological and physiological markers related to recovery-stress states? levels during the 3-month training period preceding the national championship. Ключевые слова: athletes; heart rate variability; perceived control; recovery; stress Заказать публикацию № 44 Номер заказа № 44 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 452) 3 место - продано (договор 453) Дополнительно по статье: Rationale, aims, and objectives: The article is dedicated to the search of more accurate psychodiagnostic methods and methods of evaluation that can help to define the degree of manifestation of cognitive deficiency among patients suffering from various schizophrenic disorders. The notions of cognitive deficiency and cognitive profile are analysed; we understand them as the correlation between intact and damaged components of cognitive processes and their diagrammatic representation. The authors prove that it is essential to provide a detailed scale of cognitive deficiencies detectable in case of schizophrenic disorders and to design universal algorithms that could translate the results of traditional content analysis of cognitive disorders into quantitative indicators. The article is based on the authors experiments. We examined 128 patients, among whom 76 were suffering from paranoid schizophrenia (F20 according to ICD) and 52 were suffering from schizotypal disorder (F21 according to ICD). Method: In evaluation of cognitive deficiency, we used both traditional methods devised in Russia and foreign tests that are seldom used by medical psychologists in their daily practice. We have analysed the difference in doing the cognitive tests between the groups of patients with different forms of schizophrenia and also suffering from it for different periods (up to 5 y and more than 5 y). Results: On the basis of the quantitative indicators, a cognitive profile of each particular illness was compiled. As a result, we have defined different varieties of cognitive deficiency depending on the symptoms and dynamics of the disease. Conclusion: The authors have provided a detailed description of the structure and dynamics of the cognitive deficiency in case of different forms of schizophrenia and compiled cognitive profiles based on those data. Ключевые слова: cognitive deficiency; cognitive disturbances; cognitive profile; schizophrenia Заказать публикацию № 45 Номер заказа № 45 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 462) 3 место - продано (договор 463) 4 место - продано (договор 464) Дополнительно по статье: Background: Headache is a common feature in acute cerebrovascular disease but no studies have evaluated the prevalence of specific headache types in patients with transient ischemic attacks (TIA). The purpose of the present study was to analyze all headaches within the last year and the last week before TIA and at the time of TIA. Methods: Eligible patients with TIA (n = 120, mean age 56.1, females 55%) had focal brain or retinal ischemia with resolution of symptoms within 24 h without presence of new infarction on MRI with DWI (n = 112) or CT (n = 8). All patients were evaluated within one day of admission by a single neurologist. As a control group we used patients (n = 192, mean age 58.7, females 64%) admitted with diagnoses lumbago, lumbar spine osteochondrosis or gastrointestinal ulcer. Results: One-year prevalence of migraine without aura was significantly higher in TIA patients than in controls: 20.8% and 7.8% respectively (p = 0.002, OR 3.1, 95% CI 1.6-6.2). 22 patients (18.3%) had sentinel or warning headache within the last week before TIA. At the time of TIA a new type of headache was observed in 16 patients (13.3%). No controls had a new type of headache. 12 of these 16 patients had migraine-like headache, 8 patients had tension-type-like headache and one patient thunderclap headache. Posterior circulation TIA was associated with headaches within last week before TIA and at the time of TIA much more frequently than anterior circulation TIA. Conclusions: The one year prevalence of migraine was significantly higher in TIA patients than in controls and so was the prevalence of headache within the last week before TIA and at the time of TIA. A previous headache that worsens and a new type of headache can be a warning of impending TIA. Ключевые слова: Migraine; Secondary headache disorders; TIA; Transient ischemic attack; Warning headache Заказать публикацию № 46 Номер заказа № 46 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 472) 3 место - продано (договор 473) 4 место - продано (договор 474) Дополнительно по статье: Background: Inherited abnormalities of perception, recognition, and attention to faces have been implicated in the etiology of autism spectrum disorders (ASD) including abnormal components of event-related brain potentials (ERP) elicited by faces. Methods: We examined familial aggregation of face processing ERP abnormalities previously implicated in ASD in 49 verbal individuals with ASD, 36 unaffected siblings (US), 18 unaffected fathers (UF), and 53 unrelated controls (UC). The ASD, US, and UC groups ranged in age from 12 to 21 years, the UF group ranged in age from 30 to 56 years. ERP responses to images of upright and inverted faces and houses were analyzed under disparate EEG reference schemes. Results: Face-sensitive features of N170 and P1 were readily observed in all groups. Differences between ASD and control groups depended upon the EEG reference scheme. Notably, the superiority of face over object for N170 latency was attenuated in ASD subjects, but not their relatives; this occurred exclusively with the average reference. The difference in N170 amplitude between inverted and upright faces was reduced in both ASD and US groups relative to UC, but this effect was significant only with the vertex reference. Furthermore, similar group differences were observed for both inverted faces and inverted houses, suggesting a lack of face specificity for the attenuation of the N170 inversion effect in ASD. Conclusion: The present findings refine understanding of face processing ERPs in ASD. These data provide only modest evidence for highly-selective ASD-sensitive ERP features, and underscore the sensitivity of these biomarkers to ERP reference scheme. These schemes have varied across published studies and must be accounted for in future studies of the relationship between these commonly acquired ERP characteristics, genotype, and ASD. Ключевые слова: Autistic disorder; Electrophysiology; Endophenotype; ERP; N170 Заказать публикацию № 47 Номер заказа № 47 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 482) 3 место - продано (договор 483) Дополнительно по статье: Background: The length ratio of the second to the fourth finger (2D:4D) is a possible biomarker of prenatal sex hormone levels, which play a significant role in determining sex-related body traits. Aims: To evaluate the value of the 2D:4D ratio in a Mordovian sample and to test the associations between the 2D:4D ratio and sexually dimorphic morphological traits, such as height and body weight, body mass index, waist and hip circumference, the waist-to-hip ratio, handgrip strength and the skinfold thickness. Subjects and methods: The sample studied included 106 individuals of Mordovian ethnicity: 58 males and 48 females, 16?23 years old. The associations between the 2D:4D ratio and morphological traits were evaluated by multivariate regression analysis and correlation analysis. Results: The 2D:4D ratio in males was significantly lower than in females. Most of the associations of the 2D:4D ratio with morphological traits were statistically insignificant. The 2D:4D ratio is only significantly correlated with skinfold thickness of the forearm and the abdomen in females. Conclusion: The association between the 2D:4D ratio and skinfold thickness is indicative of the role of prenatal sex hormones in shaping the body fat distribution in females, along with the significant impact of sex hormones at puberty. Ключевые слова: Body morphology; digit ratio; Mordvins; skinfold thickness Заказать публикацию № 48 Номер заказа № 48 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 492) 3 место - продано (договор 493) 4 место - продано (договор 494) 5 место - продано (договор 495) 6 место - продано (договор 496) 7 место - продано (договор 497) Дополнительно по статье: Glycans and anti-glycan antibodies (AGAs) are essential for infiltration of inflammatory cells in various allergies. The glycocalyx structure of the cells is modified during disease progression, and this modification is possible to evaluate by assessment of AGAs. A printed glycan array with 55 immobilized glycans and immobilized antibodies to IgG, IgA, and IgM was used to study the changes in AGA profiles in bronchial asthma (BA). Levels of antibodies to certain glycans in BA patients statistically differed from levels in healthy donors (p 0.0007 by the Mann-Whitney test); the glycan set included 6Su-6`-SiaLec, Sia LeX, Sia6Htype2; T, Man1-4GlcNAc, and Man1-4Man. The obtained results help to better understand the mechanisms of the cell-mediated immune response in bronchial asthma and other types of allergic reactions. Ключевые слова: allergy; anti-glycan antibodies; bronchial asthma; galectins; glycan array; immune response; siglecs Заказать публикацию № 49 Номер заказа № 49 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 502) 3 место - продано (договор 503) Дополнительно по статье: The article reports two cases of seminal vesicle cysts with ipsilateral renal agenesis in children. The congenital nature of this condition, characteristic features of the clinical manifestation of seminal vesicle cysts makes it difficult to recognize this rare genitourinary disease. Using current methods of diagnosis and surgical treatment result in successful outcomes. Ключевые слова: children; cyst of the seminal vesicle; kidney aplasia Заказать публикацию № 50 Номер заказа № 50 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 512) 3 место - продано (договор 513) 4 место - продано (договор 514) 5 место - продано (договор 515) 6 место - продано (договор 516) 7 место - продано (договор 517) Дополнительно по статье: The article presents, on the basis of twenty-year monitoring of trophic status of recruits (1995-2015) drafted to Kola trans-polar territories, dependence of individuals with undernourishment and lower nutrition from national macro-economic indices during the period after expressed crisis economic occurrences percentage of individuals with lower trophic status increased. The article proposes technique of social economic monitoring of accessibility of food market in all territories and at all levels of executive authorities based on analysis of trophic status of minors according results of dispensarization. The school meals is proposed to be included into the education standard of secondary school with the purpose of health promotion of the youth. Ключевые слова: body mass index; macroeconomic; marine medicine; meals status; social hygienic monitoring Заказать публикацию № 51 Номер заказа № 51 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 522) 3 место - продано (договор 523) 4 место - продано (договор 524) Дополнительно по статье: The article presents the results of psychic distress analysis in schoolchildren, diagnosed with arterial hypertension (AH) and ischemic heart disease (IHD). In accordance with the obtained results, the directions were outlined of a complex of measures for psychological correction of the schoolchildren, suffering from these cardiovascular diseases, that will make it possible to increase the effectiveness of prevention and therapy. Ключевые слова: Arterial hypertension; Cardiovascular diseases; Ischemic heart disease; Psychic distress Заказать публикацию № 52 Номер заказа № 52 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 532) 3 место - продано (договор 533) 4 место - продано (договор 534) 5 место - продано (договор 535) 6 место - продано (договор 536) Дополнительно по статье: Purpose: To review our experience with peripherally inserted central catheters in pediatric cancer patients. Methods: The analysis included 353 patients (3 months up to 17 years, mean age 11.2 years) with a variety of cancers diseases, which in 2011?2016, 354 peripherally inserted central catheters were placed. All settings are carried out using ultrasound guidance. In 138 (39%) patients, external anatomical landmarks were used and in 216 (61%) intraoperative fluoroscopy. Results: Maximal duration of the line was 1.3 years, the lowest 1.5 months, and average 6.3 months. Among the technical difficulties during placement, most frequently have been the migration of the distal end of the catheter into the internal jugular vein against blood flow?32 (9%) patients. In one (0.3%) case, we were unable to catheterize the patient?s vein. Among the most common complications of operation were marked peripherally inserted central catheter clot occlusion of the lumen?26 (7.3%) cases. Symptomatic catheter-related thrombosis was observed in 16 (4.5%) cases. Catheter-related blood stream infections were not reported. Removal of peripherally inserted central catheters related to the complications was performed in 30 (8.5%) patients who were later implanted venous ports. Conclusion: Peripherally inserted central catheters are recommend to use in the treatment of children with cancer. There should be trained nursing staff to minimize the risk of complications. Ключевые слова: Pediatric oncology; peripherally inserted central catheter; venous access Заказать публикацию № 53 Номер заказа № 53 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 542) 3 место - продано (договор 543) 4 место - продано (договор 544) 5 место - продано (договор 545) Дополнительно по статье: The article presents the results of an empirical study of the development level of such regulatory skills, as ?goal-setting?, ?planning?, ?modelling? and ?results? evaluation? in gifted adolescents. In order to evaluate the regulatory skills in adolescents, we developed and standardized activity-oriented tasks that allowed assessing specifically the defined skills, rather than the self-esteem of their presence. Considering the age specifics of the participants, the tasks were ranged according to their difficulty: for 12-13-year-old adolescents (students of 6-7th grades), and for 14-16-year-old adolescents (students of 8-9th grades). For the first time, we revealed and described the specifics offunctioning of the conscious activity self-regulation system in the gifted adolescents. We described the defects of self-regulation in thefunctional segments and possibilities of their compensation. Ключевые слова: Conscious self-Regulation of activity; Gifted adolescent; Regulatory skills: ?goal-setting??planning?? modelling??results? evaluation? Заказать публикацию № 54 Номер заказа № 54 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 552) 3 место - продано (договор 553) Дополнительно по статье: The length ratio of the second to the fourth finger (2D:4D) is a possible biomarker of prenatal sex hormone levels, which play a significant role in determining the sex-related body traits. The aim of this study was to assess the association between the 2D:4D ratio and morphological characteristics, related to sexual dimorphism. We analyzed a group of Russian males (N = 169) and females (N = 193) aged between 17 and 27 years (with mean ages of 18.6?1.50 and 18.9?1.85, respectively) for the association between the 2D:4D ratio and a wide range of morphological characteristics, some of which were considered in this aspect for the first time. The 2D:4D ratio in males was significantly lower than in females (p 0.000). A highly statisti-cally significant correlation was found between 2D:4D and sexually dimorphic morphological traits in the total sample. The association of 2D:4D ratio with morphological signs of masculinity/femininity within male and female samples were revealed only as a trend, which was more distinct for the functional indicators (handgrip strength). Ключевые слова: Digit ratio; Femininity; Masculinity; Morphological traits; Sexual dimorphism Заказать публикацию № 55 Номер заказа № 55 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 562) 3 место - продано (договор 563) 4 место - продано (договор 564) 5 место - продано (договор 565) 6 место - продано (договор 566) 7 место - продано (договор 567) Дополнительно по статье: Histones and their posttranslational modified forms play pivotal roles in chromatin functioning and gene transcription. Also, histones are harmful when they enter the intercellular space; their administration to animals results in systemic inflammatory and toxic responses. Autoantibodies having enzymatic activities (abzymes) are the specific feature of several autoimmune and viral diseases. Electrophoretically homogeneous IgGs containing no canonical proteases were purified from sera of HIV-infected patients by using several affinity chromatographies. In contrast to known canonical proteases, Abs from HIV-infected patients hydrolyzed exclusively only histones but no other control globular proteins. The H3 and H4 histone cleavage sites by antihistone IgGs were determined by matrix-assisted laser desorption/ionization mass spectrometry for the first time. Two clusters of H3 hydrolysis contain major () and minor (*) cleavage sites: 18-K*Q*LATK*AAR*KSA*P-30 and 34-G*VK*KPHR*YRPGTVA*L*R-50. H4 histone has only 1 cluster of cleavage sites containing additionally moderate () cleavage sites: 15-AKRHRKVLRD*NIQGIT*K-31. Sites of these histones cleavage correspond mainly to their known epitopes. It was surprising that most of the cleavage sites of histones are involved in the interaction with DNA of nucleosome core. Because histones act as damage-associated molecules, abzymes against H3 and H4 can play important role in pathogenesis of AIDs and probably other viral and immune diseases. Copyright Ключевые слова: catalytic antibodies; HIV-infected patients; human blood antibodies; interaction of histone cleavage sites with DNA of nucleosome core; specific hydrolysis of H3 and H4 histones Заказать публикацию № 56 Номер заказа № 56 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 572) 3 место - продано (договор 573) 4 место - продано (договор 574) 5 место - продано (договор 575) 6 место - продано (договор 576) 7 место - продано (договор 577) Дополнительно по статье: Efficacy and safety of tocilizumab (TCZ), an interleukin-6 receptor inhibitor, were demonstrated in juvenile idiopathic arthritis (JIA) with polyarticular course (pJIA) in the CHERISH trial. This observational, III phase study evaluated long-term treatment of TCZ in pJIA patients was conducted by members of the Pediatric Rheumatology International Trials Organization (PRINTO) from Poland and Russia. Forty-one patients, who had completed the CHERISH core study (104 weeks), were extensionally treated with TCZ (8 mg/kg, intravenous infusion every 4 weeks). Total treatment time was from 131 to 193 weeks. The long-term safety (the primary endpoint) and efficacy were evaluated. All patients achieved ACR70 response in the core study and continued to achieve at least ACR50 response up to week 24 of this study. The safety population comprised 46.41 patient-years (PY). Rates per 100 PY of adverse (AEs) and serious events (SAEs) were 181.0 and 6.46, respectively. Pharyngitis and respiratory tract infections were the most common AEs. Except one AE (severe neutropenia), all others were classified as mild (24.4%) or moderate (29.3%). The incidence of SAEs was low (7.3%). No new safety findings were observed. The safety profile of over 2.5-year treatment with TCZ is consistent with the pre-marketing CHERISH clinical trial. Presented data and continued efficacy response support the use of TCZ in pJIA. EUDRACT No: 2011-001607-12. https://clinicaltrials.gov/ct2/show/study/NCT01575769?term=ML27783. Ключевые слова: Biologicals; Juvenile idiopathic arthritis; Tocilizumab; Treatment Заказать публикацию № 57 Номер заказа № 57 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 582) 3 место - продано (договор 583) 4 место - продано (договор 584) 5 место - продано (договор 585) 6 место - продано (договор 586) Дополнительно по статье: Background: The diagnosis of transient ischemic attacks is fraught with problems. The inter-observer agreement has repeatedly been shown to be low even in a neurological setting, and the specificity of the diagnosis is modest to low, reflected in a poor separation of transient ischemic attacks and mimics, particularly migraine with aura with its varied symptomatology. In other disease areas, explicit diagnostic criteria have improved sensitivity and specificity of diagnoses. We therefore present novel explicit diagnostic criteria for transient ischemic attacks tested for sensitivity and for specificity against migraine with aura. Methods: The proposed criteria were developed using the format of the international headache classification. We drew upon the existing literature about clinical characteristics and diagnosis of migraine with aura and transient ischemic attacks. We tested the criteria for sensitivity in a prospectively-collected material of 120 patients with transient ischemic attacks diagnosed before we developed the criteria using extensive semi-structured interview forms in the acute phase after admission. Eligible patients had focal brain or retinal ischemia with resolution of symptoms within 24 hours without presence of new infarction on magnetic resonance imaging with diffusion weighted imaging (n = 112) or computed tomography (n = 8). These criteria were also tested for specificity against a Danish (n = 1390) and a Russian (n = 152) material of patients with migraine with aura diagnosed according to the International Classification of Headache Disorders edition 3 (beta). Results: The sensitivity of the proposed criteria was 99% in patients with transient ischemic attacks. The specificity was 95% in the Danish material of patients with migraine with aura and 96% in the Russian material. Conclusions: Proposed explicit diagnostic criteria for transient ischemic attacks showed both high specificity and sensitivity. They are likely to improve the emergency room diagnosis of transient ischemic attacks. Further testing in unselected materials referred to transient ischemic attacks clinics was beyond the scope of the present study but is recommended for future study. Ключевые слова: diagnosis of TIA; diagnostic criteria of TIA; migraine with aura; Transient ischemic attack Заказать публикацию № 58 Номер заказа № 58 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 592) 3 место - продано (договор 593) 4 место - продано (договор 594) 5 место - продано (договор 595) 6 место - продано (договор 596) Дополнительно по статье: This article examines relationships between social identities and acculturation strategies of Russians (the ethnic minority) in the Republic of North Ossetia?Alania (RNO-A). The sample included 109 grandparent?parent?adolescent triads from ethnically Russian families (N = 327). We assessed acculturation strategies, ethnic and national identities (identification with the Russian Federation), republican identity (with the RNO-A), regional identity (with North Caucasus), and religious identity. EFA combined five identities in two factors, labeled Russian ethnocultural identity (comprising ethnic, national, and religious identities) and North-Caucasian regional identity (comprising identities involving the republic and region). The means of the identity factors remained remarkably stable across generations, with a somewhat stronger Russian ethnocultural identity. A structural equation model revealed that Russian ethnocultural identity was a negative predictor of assimilation (the least preferred acculturation strategy), whereas North-Caucasian regional identity was a positive predictor of integration (the most preferred strategy) in all generations. We concluded that Russian ethnocultural identity is important for maintaining the heritage culture whereas North-Caucasian regional identity promotes participation of ethnic Russians in the multicultural North-Ossetian society. Ключевые слова: assimilation; ethnic Russian minority; generation; integration; North Caucasus; social identity Заказать публикацию № 59 Номер заказа № 59 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 602) 3 место - продано (договор 603) 4 место - продано (договор 604) 5 место - продано (договор 605) Дополнительно по статье: Objective To study the structure of maternal mortality caused by abortion in the Tula region. Methods The medical records of deceased pregnant women, childbirth, and postpartum from January 01, 2001, to December 31, 2015, were analyzed. Results Overall, 204,095 abortion cases were recorded in the Tula region for over 15 years. The frequency of abortion was reduced 4-fold, with 18,200 in 2001 to 4,538 in 2015. The rate of abortions per 1,000 women (age 15?44 years) for 15 years decreased by 40.5%, that is, from 46.53 (2001) to 18.84 (2015), and that of abortions per 100 live births and stillbirths was 29.5%, that is, from 161.7 (2001) to 41.5 (2015). Five women died from abortion complications that began outside of the hospital, which accounted for 0.01% of the total number. In the structure of causes of maternal mortality for 15 years, abortion represented 14.3% of the cases. Lethality mainly occurred in the period from 2001 to 2005 (4 cases). Among thematernal deaths, many women died in rural areas after pregnancy termination at 18 to 20 weeks of gestation (n = 4). In addition, three women died from sepsis and two from bleeding. Conclusion The introduction of modern, effective technologies of family planning has reduced maternal mortality due to abortion. Ключевые слова: Abortion; Family planning; Maternal mortality; Pregnancy; Sepsis Заказать публикацию № 60 Номер заказа № 60 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |