[Darya]
[Yu Long]
[Amir]
[Anh]
[Mais]
[Darya]
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2 место - продано (договор 12) 3 место - продано (договор 13) 4 место - продано (договор 14) Дополнительно по статье: Background: In Russia as in other countries introduction of infant vaccination against pertussis in 1950s led to dramatic decrease of whooping cough. The current vaccination schedule includes a 3-dose infant series and toddler booster; the pre-school booster was cancelled in 1980s and never reintroduced. Whole-cell vaccines, and in a smaller proportion acellular vaccines are used for all doses. However, pertussis incidence in urban settings is high with highest burden in school children. We conducted a study of seroprevalence of recent pertussis infection to estimate the duration of protection from the 4-dose series. Materials and methods: Sera sample from 395 St Petersburg children aged 3 years and 14 years were tested for pertussis toxin antibodies using a commercial PT ELISA test. Only children with completed 4-dose vaccination course were included in the study. Age-specific seroprevalence of recent pertussis infection was analyzed for trends. Results: Children fully vaccinated against pertussis at 3 years old had significant delays in infant vaccination schedule: only 83.5% received at least one dose of pertussis vaccine at 6 months of age and 25.6% received their toddler booster before 24 months-old. Overall, 10.6% of children demonstrated the serological signs of the infection in the last 12 months. A clear trend (r 2 = 0.692) of increasing proportion of infection in the last 12 months was observed in children who had received their last dose of vaccine 6 years and more prior to the study. Conclusion: Our study demonstrates that Russian children become susceptible to infection at or soon after entering school. The results confirm the waning of vaccine-elicited immunity around school-age and support the need for a booster dose at that age. Ключевые слова: Pertussis; Seroprevalence; Vaccines; Waning Заказать публикацию № 1 Номер заказа № 1 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 22) 3 место - продано (договор 23) Дополнительно по статье: Background: One of the topics discussed in sports science is the use of medium-chain saturated fat as an energy-saving nutrient additive when approaching high-intensity exercise. The purpose of this study was to compare the blood concentrations of medium-chain and long-chain fatty acids (FAs) across different intensity loads. Methods: Fifteen male highly trained athletes from the Russian cross-country skiing team participated in the study. Blood samples were drawn at rest, at the peak of veloergometric test with a growing exercise load till exhaustion (97-100% VO2max), and after competitions. The plasma FA profile was determined using gas-liquid chromatography. Results: We observed a substantial increase in the concentrations of capric acid (C10:0) (+164.1%), lauric acid (C12:0) (+223.9%), and myristic acid (C14:0) (+130.2%) in skiers after a sprint distance (1.3km). A less intense increase in the concentrations of these acids (p0.05) was observed after a middle length distance or cycle exercise ?until exhaustion?. No significant differences in long-chain saturated FA content relative to baselines during exercise tests or competitions were revealed. Conclusions: In conclusion, the obtained results demonstrate activation of the lipolysis and the oxidation of medium-chain FA involved in the energy supply for highly trained athletes at maximum exercise loads. Ключевые слова: Competition; Cycle exercise until exhaustion; High intensity and submaximal exercise; Medium-chain fatty acids Заказать публикацию № 2 Номер заказа № 2 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 32) 3 место - продано (договор 33) 4 место - продано (договор 34) 5 место - продано (договор 35) 6 место - продано (договор 36) Дополнительно по статье: Introduction: Spine congenital curvatures formed as a result of anomalies in the development of vertebral bodies leads to severe and rigid deformities of the spinal column in the adolescent age and are often accompanied by irreversible neurologic disorders. There for genetic markers study of the congenital malformations is an important and urgent task. Aim: The aim of the study is to determine the frequency of detoxification and reparation genes polymorphism in congenital spine deformities patients. Materials and Methods: The study of 200 children with Congenital Spine Deformities (CSD) between the age of 1 year 2 months to 16 years and 96 healthy children aged from 2 to 16 years without pathology of the spine was carried out by the methods of clinical and radiographic diagnostics. Molecular diagnostics was carried out by analysing multiple polymorphic regions in the genes of detoxification and DNA repair, which are of clinical importance due to their predisposing factors in various congenital malformations. Genotyping of the gene polymorphism was performed using Polymerase Chain Reaction (PCR) and the PCR products were visualised bygel electrophoresis. Results: The polymorphisms of the genes CYP1A2, GSTM1, GSTT1, GSTP1, NAT2, XRCC1, XRCC3 and their frequency distribution among patients with CSD and control group were investigated. Significant differences in the distribution of genotypes compared with the control group were found in the polymorphic regions of the genes CYP1A2, GSTM1, GSTT1, NAT2, XRCC3. However, in the GSTP1 and XRCC1 genes, no significant differences between the CSD patients and the control group was observed. Conclusion: All patients with congenital spine deformities had significant changes in some candidate genes alleles. It was found that the number of minor alleles in the genes under investigation correlate with the severity of congenital deformity and the variability of vertebral anomalies. It was determined that in children with multiple and combined defects in the spine development, there is a greater number of mutations in the detoxification and DNA-repair genes compared to children with isolated vertebral anomalies. Ключевые слова: Children; Detoxification; DNA repair; Molecular diagnostics Заказать публикацию № 3 Номер заказа № 3 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 42) 3 место - продано (договор 43) 4 место - продано (договор 44) Дополнительно по статье: Background A group of Russian scientists has developed Diaskintest, which comprises Mycobacterium tuberculosis-specific recombinant proteins CFP10-ESAT6, for skin testing (0.2 g/0.1 ml). Study purpose To evaluate the comparative sensitivity of TST with 2 TU PPD-L and a skin test with tuberculous recombinant allergen (Diaskintest) containing the ESAT6-CFP10 protein in children and adolescents with newly diagnosed active tuberculosis during mass screening in the primary medical service in Moscow. Materials and methods The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with active tuberculosis in 2013?2016, aged 0 to 17 years inclusive. Results From 441 patients selected for analysis 408 patients had both tests (TST with 2 TU PPD-L and Diaskintest) performed, in 193 patients both tests were given simultaneously, of them 162 patients were BCG-vaccinated. Comparative results of both tests in 408 patients with tuberculosis: at cut-off 5 mm, both tests has similar sensitivity: Diaskintest 98.3% (95% CI 97.0?99.6%), TST 98.0% (95% CI 96.7?99.4%), at cut-off 10 mm, the sensitivity decreases for both tests: Diaskintest 90.0% (95% CI 87.0?93.0%), TST 88.7% (95% CI 85.6?91.9%), but at cut-off 15 mm, the decrease in sensitivity is statistically significant: for Diaskintest 61.5% (95% CI 56.7?66.3%), and for TST 46.3% (95% CI 41.4?51.3%), p 0.0001. The results of simultaneous setting of tests on different hands in 193 people (including 162 BCG-vaccinated), do not differ from the results for 408 people. The correlation between the results of Diaskintest and TST was significant in all groups. Conclusion In children and adolescents with active tuberculosis, Diaskintest of 0.2 g/ml and the Mantoux test with 2 TU PPD-L have high sensitivity (98%) at a cut-off of 5 mm; however, at cutoff 15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux test. The advantage of Diaskintest is that, unlike the Mantoux test, it has high specificity under the conditions of mass BCG vaccination. The test is simple to carry out, and can be used in mass screening. Заказать публикацию № 4 Номер заказа № 4 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 52) 3 место - продано (договор 53) 4 место - продано (договор 54) 5 место - продано (договор 55) 6 место - продано (договор 56) Дополнительно по статье: INTRODUCTION: Surgical treatment of proximal hypospadias is associated with a number of difficulties and unsuccessful repeated interventions. The changing approaches to the treatment of hypospadias with the revision of the attitude to urethral plate provide new opportunities in resolving this problem. AIM: to improve the results of surgical correction of hypospadias by creating artificial urethra that is very close to a native one in its functional qualities. MATERIAL AND METHODS: From 2011 to 2017 . two-stage urethroplasty using Bracka technique was used in 41 patients with a proximal hypospadias aged 1-16 years. From those, 32 patients were undergone to primary intervention (78%), and 9 boys previously had unsuccessful urethroplasty performed by different techniques (22%). Oral mucosa graft was used in 9 patients (22%), and in other 32 cases inner preputial skin was harvested (78%). The classical and modified Bracka technique were performed in 19 and 22 cases, respectively. The urethral plate was preserved in 22 cases and artificial urethra was created by its tubularization, which contributes to the reduction of the required length of the harvested prepucial graft. RESULTS: The complication rate in patients after classical Bracka technique was 31.6% (n=6) in comparison with 4.5% in group of the modified urethroplasty (n=1). Thus, the efficiency of modified technique was significantly better than that of the classical intervention (0,05). CONCLUSION: The preservation and use of urethral plate for urethroplasty during the two-stage surgical correction of the proximal hypospadias allows to decrease the total length of artificial urethra and to improve the properties of the newly formed urethra. Ключевые слова: children; hypospadias; technique of Bracka; urethral plate Заказать публикацию № 5 Номер заказа № 5 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 62) 3 место - продано (договор 63) 4 место - продано (договор 64) Дополнительно по статье: In our study, the frequencies of serotonin transporter gene (5-HTT) polymorphisms and their combinations are compared in the healthy male subjects with antisocial behavior, in general, and in those with its particular forms, as well as in the reference group of MMA fighters. Subjects convicted of unlawful actions were classified into those convicted of violent crimes or non-violent ones. The group of subjects convicted of violent crimes was further subdivided into those convicted of murder, or robbery, or of inflicting grave body injuries. The group of MMA fighters was selected from the subjects without a prior history of antisocial behavior or criminal record in the subjects or their relatives. The frequency of D allele in the groups of convicted subjects and MMA fighters was higher, than in the population sample. Furthermore, the frequencies of D/D and 12/12 genotype combinations were shown to be higher in the group of convicted subjects, especially, in habitual criminals and those convicted of grave crimes or murder. The predisposition of MMA fighters to violent behavior and physical aggressive suppression of an opponent is successfully implemented in their professional career; however, this behavioral pattern appears to represent the controlled aggression. Заказать публикацию № 6 Номер заказа № 6 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 72) 3 место - продано (договор 73) 4 место - продано (договор 74) 5 место - продано (договор 75) 6 место - продано (договор 76) 7 место - продано (договор 77) Дополнительно по статье: Background: Efficacy of Helicobacter pylori eradication therapy depends on the chance of having a resistant H. pylori strain, which is ultimately related to the local antimicrobial resistance epidemiology. Aim: To assess H. pylori resistance to clarithromycin, amoxicillin, metronidazole, levofloxacin, and tetracycline in adult patients in the Smolensk region of Russian Federation over a 9-year period. Materials and methods: Biopsy samples were taken from the gastric antrum and body of 573 and 210 patients with dyspepsia symptoms and positive rapid urease test during esophagogastroduodenoscopy in 2015-2017 and 2009-2010, respectively. Antimicrobial susceptibility testing was performed for clarithromycin, amoxicillin, metronidazole, levofloxacin, and tetracycline by the agar dilution method. Results: A total of 143 strains of H. pylori isolated during 2015-2017 and 133 strains isolated during 2009-2010 were tested. Culture success rates were 30% vs 64% for the two periods. Over the 2015-2017, the prevalence of resistance to clarithromycin was 6.3%, to amoxicillin 1.4%, to metronidazole 23.8%, to levofloxacin 24.5%, and to tetracycline 0.7%. Over the 2009-2010, the corresponding resistance rates were 5.3%, 4.5%, 3.8%, 8.3%, and 0%, respectively. There were no significant increases in resistance to clarithromycin, amoxicillin, and tetracycline (P 0.05) over the 9 years period. Significant increase in resistance to levofloxacin (8.3% in 2009-2010% vs 24.5% in 2015-2017, P 0.01) and metronidazole (3.8% in 2009-2010% vs 23.8% in 2015-2017, P 0.01) was observed. Conclusions: H. pylori resistance to clarithromycin remained low in the Smolensk region of Russian Federation between 2009 and 2017. Resistance to levofloxacin and metronidazole increased between 2009 and 2017. Ключевые слова: amoxicillin; antimicrobial resistance; clarithromycin; Helicobacter pylori; levofloxacin; metronidazole Заказать публикацию № 7 Номер заказа № 7 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 82) 3 место - продано (договор 83) 4 место - продано (договор 84) 5 место - продано (договор 85) 6 место - продано (договор 86) 7 место - продано (договор 87) Дополнительно по статье: Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients. Ключевые слова: Coeliac disease; Paediatric population; Questionnaire; Screening; Symptoms Заказать публикацию № 8 Номер заказа № 8 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 92) 3 место - продано (договор 93) 4 место - продано (договор 94) 5 место - продано (договор 95) 6 место - продано (договор 96) Дополнительно по статье: The aim of this study was to investigate the metal content in the hair of children living near abandoned nonferrous metal mines located in the rural settlements Tubinsk, Ishmurzino and Semenovsk the South Urals (Russia), and in the soils obtained from the same area. The hair and soils samples were examined for the presence of the following metals: copper (Cu), zinc (Zn), iron (Fe), cobalt (Co), nickel (Ni), manganese (Mn), lead (Pb) and cadmium (Cd). The results of this study showed that soil from this territory contained an increased level of Cu, Fe, Zn, Mn, Pb, Cd, exceeding the maximum permissible concentration (MPC) 38.3, 16.8, 4.5, 1.5, 1.4, 1.5 - fold, respectively. These values are indicative of severe soil pollution in the studied locality, thus calling for further detailed investigations. Mineral analysis of the hair samples was performed using a combination of atomic emission spectrometry and inductively coupled plasma mass spectrometry. In the hair samples, positive correlations between the following pairs of the studied metals were observed (p 0.05): Pb-Cd (r= 0.73), Mn-Cd (r= 0.79), Fe-Cd (r= 0.56), Fe-Co (r= 0.85), Mn-Co (r= 0.65), Ni-Co (r= 0.67), Mn-Fe (r= 0.78), Ni-Fe- (r= 0.45), Pb-Fe (r= 0.46); Pb-Mn (r= 0.58). The comparison between Zn and Pb showed a negative linear correlation for the hair samples (r= 0.50; p0.05) and for the soil samples (r= 0.68; p0.05) suggesting that the presence of Zn and Pb in the hair could correlate with the content of these two metals in the soil. Comparison of the data on hair from this study with the average reference data for Russia showed the presence of an excess of Fe, Mn and Zn in the hair samples of the majority of the studied population: 100, 72.5 and 54.5 percent, respectively. We also observed an excess of Ni, Cd and Pb in a small number of children (in 18.2, 13.6 and 9.1 percent of the studied population, respectively). A deficiency of Cu and Co, the essential microelements for human health, was found in 27.3 percent of the studied population. The results of this study could be used to analyze the internal toxic metal burden in contaminated areas of Bashkortostan and could also serve as reference for further studies. Ключевые слова: Abandoned mines; Biomonitoring; Children; Hair; Toxic metals; Trace elements Заказать публикацию № 9 Номер заказа № 9 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 102) 3 место - продано (договор 103) 4 место - продано (договор 104) 5 место - продано (договор 105) 6 место - продано (договор 106) Дополнительно по статье: Aims: Chronic disorders, such as cardiovascular disease, cancer, respiratory diseases and diabetes, are the leading cause of mortality globally, representing 68% of all recorded deaths. The incidence of chronic disease and multiple chronic disease is rising across the world, but relatively little is known about the impact of multi-morbidities on the life experiences of those individuals who encounter them. In this paper, we examine and quantify the relationship between chronic illness, multi-morbidity and the individual self-assessed health of the Russian population using individual-level Russian data and a novel quantitative technique. Methods: We apply a partial proportional odds framework to a rich data set incorporating demographic, socio-economic and health indicators in Russia. Results: We find that individuals with chronic conditions report significantly lower levels of health than those without chronic conditions, but that the strength of the effect is much more pronounced for males than for females (e.g. neurological disease: odds ratio [OR]=4.81 for men; OR=1.86 for women)). As the number of co-morbidities increases, there is a dramatic decrease in the likelihood of reporting good health for both males and females, but for males there is a greater increase in the likelihood of reporting bad health (OR=49.31 for males with 5 diseases; OR=28.05 for females). Conclusions: More than 40% of Russians currently live with multi-morbidity, and this group is at the highest risk of reporting poor self-rated health. This research adds to the body of evidence demonstrating the challenges facing health-care systems as new patterns of disease take hold in contemporary society. Ключевые слова: chronic illness; gender; multi-morbidity; partial proportional odds model; RLMS; Russia; Self-assessed health Заказать публикацию № 10 Номер заказа № 10 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 112) 3 место - продано (договор 113) 4 место - продано (договор 114) Дополнительно по статье: We aimed to develop and validate a model of associations of perceived threat of homosexuals with lay beliefs about causes of homosexuality, group entitativity of homosexuals, approval of social action strategies targeting homosexuals, and support for their rights using original Russian-language measures. We tested the model in two samples of social network users (n = 1,007) and student respondents (n = 292) using structural equation modeling and path analysis. Attribution of homosexuality to social causes was a positive predictor of perceived threat of homosexuals, whereas biological causes showed an inverse effect. Perceived threat predicted approval of discriminatory strategies targeting homosexuals and lack of support for their rights and fully mediated the effects of causal beliefs on these variables. Group entitativity of homosexuals was a positive predictor of perceived threat and a significant moderator of its effects on support for punishment and medical treatment of homosexuals. We discuss the findings with reference to the Russian social context. Ключевые слова: attitudes to homosexuals; homonegativity; Homosexuality; institutionalized homophobia; intergroup threat theory; support for rights Заказать публикацию № 11 Номер заказа № 11 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 122) 3 место - продано (договор 123) 4 место - продано (договор 124) Дополнительно по статье: We aimed to develop and validate a model of associations of perceived threat of homosexuals with lay beliefs about causes of homosexuality, group entitativity of homosexuals, approval of social action strategies targeting homosexuals, and support for their rights using original Russian-language measures. We tested the model in two samples of social network users (n = 1,007) and student respondents (n = 292) using structural equation modeling and path analysis. Attribution of homosexuality to social causes was a positive predictor of perceived threat of homosexuals, whereas biological causes showed an inverse effect. Perceived threat predicted approval of discriminatory strategies targeting homosexuals and lack of support for their rights and fully mediated the effects of causal beliefs on these variables. Group entitativity of homosexuals was a positive predictor of perceived threat and a significant moderator of its effects on support for punishment and medical treatment of homosexuals. We discuss the findings with reference to the Russian social context. Ключевые слова: attitudes to homosexuals; homonegativity; Homosexuality; institutionalized homophobia; intergroup threat theory; support for rights Заказать публикацию № 12 Номер заказа № 12 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 132) 3 место - продано (договор 133) Дополнительно по статье: The term social jet lag was introduced for defining the conflict between social and biological clocks due to the general practice of shifting weekday risetime on early morning hours. The phase delay of the sleep-wake cycle during adolescence is one of the most remarkable features of the ontogenesis of sleep that is incompatible with early school start times. It was previously proposed that the process of accumulation of sleep pressure during wakefulness is slowing down in post-pubertal teens to allow them to stay awake for a longer period of time thus causing the delay of their bedtime. In order to examine this proposition, we traced the ontogeny of social jet lag using sleep times reported for 160 samples of study participants of different ages as an input to a model of sleep-wake regulatory process. The simulations suggested that a gradual change in just one of the models parameters, the time constant of wakefulness phase of the sleep-wake regulatory process, might explain the association of the transition between childhood and adulthood with the prolongation of time staying awake, delay of sleep time, and reduction of sleep duration. We concluded that the implication of the sleep-wake regulating model would be of help for understanding precisely how social jet lag varies with age and what are the chronophysiological causes of this variation. Copyright Ключевые слова: Maturational changes; Simulation; Sleep debt; Sleep-wake regulation; Somnostat; Two-process model Заказать публикацию № 13 Номер заказа № 13 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 142) 3 место - продано (договор 143) 4 место - продано (договор 144) Дополнительно по статье: Older adults demonstrate a slower speed of linguistic processing, including sentence processing. In nonlinguistic cognitive domains such as memory, research suggests that age-related slowing of processing speed may be a strategy adopted in order to avoid potential error and/or to spare cognitive resources. So far, very few studies have tested whether older adults slower processing speed in the linguistic domain has a strategic nature as well. To fill this gap, we tested whether older adults can maintain language processing accuracy when a faster processing speed is enforced externally. Specifically, we compared sentence comprehension accuracy in younger and older adults when sentences were presented at the participants median self-paced reading speed versus twice as fast. We hypothesized that an external speed increase will cause a smaller accuracy decline in older than younger adults because older adults tend to adopt self-paced processing speeds further away from their performance limits. The hypothesis was not confirmed: The decline in accuracy due to faster presentation did not differ by age group. Thus, we found no evidence for strategic nature of age-related slowing of sentence processing. On the basis of our experimental design, we suggest that the age-related slowing of sentence processing is caused not only by motor slowdown, but also by a slowdown in cognitive processing. (PsycINFO Database Record . Ключевые слова: aging; language and aging; processing speed; processing strategies; sentence comprehension Заказать публикацию № 14 Номер заказа № 14 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 152) 3 место - продано (договор 153) Дополнительно по статье: Purpose House dust mites Dermatophagoides pteronyssinus are the main source of major inhalatory allergens inducing inflammatory response. Mite extract contain both allergenic proteins and lipopolysaccharides (LPS). The main allergenic protein, Der p 2, is a functional homolog of sMD-2, a protein providing blood cell response on LPS. Der p 2 may restore the response to LPS in absence of MD-2, but its interaction with LPS in whole blood is unknown. We studied the effect of Der p 2 on LPS-mediated activation of human whole blood cells. Methods Interaction of Der p 2 and LPS was studied on eight healthy donors. The whole blood was incubated with extract of house dust mite Dermatophagoides pteronyssinus (DP-e), recombinant antigenic protein Der p 2 variant 5 (rDep 2), Escherichia coli lipopolysaccharide and their combination. Supernatants were collected for ELISA analysis of protein content. Activation degree was determined by change in concentration of TNF-, IL-8, IL-1Ra cytokines and sMD-2 protein. Results extract of mite Dermatophagoides pteronyssinus (DP-e) possessed weak inherent activity and did not cause significant increase of cytokine production. Simultaneous activation of blood cells by LPS and DP-e led to considerable increase of pro-inflammatory cytokine production. We have shown the intrinsic inducing activity of Der p 2 allergen on sMD-2 protein and TNF- cytokine expression. Conclusions Der p 2 allergen enhances the response of human whole blood cells to external LPS by inducing additional expression of LPS-transporting protein sMD-2. The obtained data show an important role of LPS contamination of allegrens in the progress of allergic inflammatory response. Заказать публикацию № 15 Номер заказа № 15 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 162) 3 место - продано (договор 163) 4 место - продано (договор 164) 5 место - продано (договор 165) 6 место - продано (договор 166) 7 место - продано (договор 167) Дополнительно по статье: Background: To investigate the skeletal development of HIV infected children through a morphological analysis of the cervical vertebrae (CV) in lateral cephalometric radiographs. Material and Methods: The sample consisted of 86 lateral cephalometric radiographs of male and female children aged between 6 and 14 years old. The radiographs were equally distributed in groups 1 (HIV infected children) and 2 (non-infected children, paired by sex and age). Two examiners analyzed the CV according to the method of Hassel and Farman (1995). Spearman correlation coefficient was used to associate age and skeletal development within groups, while Mann-Whitney test compared the skeletal development between groups. Results: The correlation of age and skeletal development in group 1 reached 0.17, 0.27 and 0.27 (p0.05) for C2, C3 and C4, respectively, while in group 2 it reached 0.65, 0.54 and 0.60, respectively (p[removed]0.05). Conclusions: HIV infected and non-infected children showed a similar development of the CV. However, the weak correlation between age and CV development in HIV infected children highlights the need for careful decisions prior to therapeutic approaches-especially those founded on the prediction of skeletal development, such as maxillofacial surgeries, and orthopedic and orthodontic procedures. Ключевые слова: Cervical vertebrae; Growth and development; HIV; Radiology Заказать публикацию № 16 Номер заказа № 16 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 172) 3 место - продано (договор 173) 4 место - продано (договор 174) 5 место - продано (договор 175) Дополнительно по статье: Aims: To explain comprehensively variations in adult male mortality rate in Europe, and in particular, high mortality in some East European countries with particular focus on specific patterns of alcohol consumption. Short summary: Per capita distilled spirits consumption is found to be the strongest determinant of the adult male mortality rate in Europe as soon as the unrecorded alcohol consumption is taken into account. It turns out to be much stronger than the other tested significant determinants such as per capita health expenditures, smoking prevalence, consumption of hard drugs and per capita consumption of vegetables and fruit. Methods: Ordinary least squares (OLS) multiple regression with adult male mortality rate as a dependent variable, and various indicators of alcohol and drug consumption as well as logarithm of gross domestic product (GDP) per capita, logarithm of total per capita health expenditures, latitude (climatic factors), per capita fruit and vegetable consumption, smoking prevalence as independent factors. Results: Per capita distilled spirits consumption turns out to be the strongest determinant of the adult male mortality rate in Europe as soon as the unrecorded alcohol consumption is taken into account. It turns out to be much stronger than the other tested significant determinants of the adult male mortality rate such as per capita health expenditures, smoking prevalence, consumption of hard drugs and per capita consumption of vegetables and fruit. Still, higher per capita wine consumption has turned out to be a marginally significant determinant of the higher adult male mortality rate in some tests. Latitude, beer and soft drug consumption have turned out insignificant in this study. Conclusions: Spirits consumption is a major risk factor of adult male mortality, with significantly greater impact compared to beer and wine. Therefore, reduction in distilled spirits consumption in hard liquor drinking areas should be a major target in health policy. Заказать публикацию № 17 Номер заказа № 17 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 182) 3 место - продано (договор 183) Дополнительно по статье: Objective: Eating disorders are a cause of the recent obesity epidemic. Food addiction (FA) and factors associated with eating disorders have not been adequately studied in adolescents. Method: The final study sample included 1,144 students. Study participants were asked to indicate their age, sex, and month of birth and fill out the Yale Food Addiction Scale for Children and Zung Self-Rating Depression Scale. Results: Of the total number of adolescents studied, 4.5% had FA. It was found that an increased rate of FA diagnosis existed in adolescents with moderate-to-severe depression (P 0.000), overweight and obese individuals (P 0.002), girls (P 0.038), and the 17- to 18-year-old age group (P 0.007). Conclusion: The data indicate that FA is positively associated with depression, obesity, age, and sex. Ключевые слова: adolescent; BMI; depression; food addiction Заказать публикацию № 18 Номер заказа № 18 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 192) 3 место - продано (договор 193) 4 место - продано (договор 194) 5 место - продано (договор 195) 6 место - продано (договор 196) Дополнительно по статье: Background: It is current practice for physicians to use the Prontosan ? range of products in children based on their personal clinical experience, despite the lack of safety data in this population. This retrospective data review was designed to obtain information on the safety profile of the Prontosan ? range of products in children in routine clinical practice. Methods: Data from newborns, infants and children with burns treated with the Prontosan ? range were collected retrospectively from patient medical records. Results: The majority of children treated for burns (80.1%) were under the age of four. More boys than girls were subject to burn injury (58.1% vs. 41.9%). The majority of burns (74.7%) were partial thickness burn (IIa and IIb). Safety was analysed based on the adverse events/reactions, infections and interactions/symptoms related to Prontosan ? reported in the CRFs. AEs were reported in five children after the use of Prontosan ? products: itching (3 cases), rash (1 case) and hypergranulating tissue (1 case). No event was severe and all events resolved favourably with good healing results. In addition, 11 patients developed clinical signs of infection during treatment (mainly Staphylococcus aureus). Conclusions: The Prontosan ? range of products is demonstrated as safe and tolerable for use in children as part of burn treatment. Inclusion of this range of products in the protocol of paediatric burn care allows a good healing process starting with appropriate wound cleansing and maintaining moist wound environment. Ключевые слова: Burns; Paediatrics; Polyhexanide; Prontosan ? Заказать публикацию № 19 Номер заказа № 19 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 202) 3 место - продано (договор 203) 4 место - продано (договор 204) Дополнительно по статье: Feedback processing is an important aspect of learning. In the human brain, feedback processing is often examined by measuring an event-related potential, the feedback-related negativity component. Typically, the feedback-related negativity component is investigated by directly comparing gain with loss feedback randomized across trials; however, this method does not control for confounds associated with unexpected feedback. For this study we used a blocked design gambling task to investigate the sensitivity of feedback-related negativity to positive and negative feedback separately for gains and losses. While there appeared to be no significant feedback-related negativity in the loss domain, results revealed an enlarged feedback-related negativity during the omission of gains compared to the reception of gains. These findings further support the reward positivity hypothesis which declares that the feedback-related negativity is associated with the processing of outcomes in the context of gains as opposed to losses, irrespective of unexpectedness. Ключевые слова: EEG; ERP; Feedback learning; Feedback-related negativity; FRN; Gambling; Reward; Reward positivity hypothesis Заказать публикацию № 20 Номер заказа № 20 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 212) 3 место - продано (договор 213) Дополнительно по статье: The n-back task is likely the most popular measure of working memory for functional magnetic resonance imaging (fMRI) studies. Despite accumulating neuroimaging studies with the n-back task and children, its neural representation is still unclear. fMRI studies that used the n-back were compiled, and data from children up to 15 years (n = 260) were analyzed using activation likelihood estimation. Results show concordance in frontoparietal regions recognized for their role in working memory as well as regions not typically highlighted as part of the working memory network, such as the insula. Findings are discussed in terms of developmental methodology and potential contribution to developmental theories of cognition. Заказать публикацию № 21 Номер заказа № 21 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 222) 3 место - продано (договор 223) Дополнительно по статье: This study was designed to evaluate synthetic cannabinoid (SC)-induced psychotic disorders in terms of their structure and clinical characteristics among hospitalized patients in Russia. It was a longitudinal, observational cohort study which included a total of 46 male patients who underwent the inpatient treatment in the intensive care unit or emergency department due to the SC-induced psychoses. Data on sociodemographic and disease-related characteristics, psychometric assessment scales obtained in face-to-face interviews, were recorded in all patients. The duration of catamnestic follow-up period was 2 years, with the major focus on manifestation of the schizophrenic process. Mean (SD) age of the patients with psychotic disorders induced by the SC use was 23.2 (3.5) years. Among 46 patients, 29 (63%) were SC-dependent and 17 (37%) were diagnosed with SC abuse. Average age at onset was 16.4 for psychoactive substances and 19.7 years for SC use. Marijuana was the most common first used substance. Based on our observations, we identified four clinical variants of the SC-induced psychoses. Our findings revealed that psychotic disorders are typical for the SC intoxication and most commonly influence young adults. Based on our observations, we identified four clinical variants of the SC-induced psychoses and revealed the signs which may indicate them. This study emphasizes the role of appropriate psychiatric management of SC-induced psychoses, since often only catamnestic long-term follow-up enables clinicians to determine the correct diagnosis and reveal the manifestation of the schizophrenic process. Ключевые слова: addiction; cannabinoid use disorder; differential diagnosis; patients; psychopathology; psychosis; substance-induced psychosis; Synthetic cannabinoid; withdrawal Заказать публикацию № 22 Номер заказа № 22 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 232) 3 место - продано (договор 233) 4 место - продано (договор 234) 5 место - продано (договор 235) Дополнительно по статье: Modern methods of orthodontic treatment of dentoalveolar anomalies with fixed appliances often lead to oral mucosa traumatic lesions causing discomfort, pain, inflammation. The aim of the work was to study the prevalence, structure, causes of traumatic lesions, as well as the development and assessment of efficiency of clinical application of phytofilm for their treatment. An optimal composition of the dental film composed of dry extracts of marigoldand yarrow and propolis tincture for the treatment of traumatic lesions in orthodontic patients was developed and pathogenetically justified.While managing traumatic lesions of the oral mucosa during orthodontic treatment, evidence has been obtained that the use of new dental film of the original composition made it possible to obtain positive clinical results: reduction of treatment duration, rapid and effective relief of traumatic lesion pain, restoration of initial structural and functional parameters of oral mucosa and its physiological sensitivity. Ключевые слова: Orthodontic treatment; Phytofilm; Traumatic lesion of oral mucosa Заказать публикацию № 23 Номер заказа № 23 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 242) 3 место - продано (договор 243) 4 место - продано (договор 244) 5 место - продано (договор 245) Дополнительно по статье: Theresults of epidemiological study on the prevalence and structure of dentofacial anomalies and the severity of endemic dental fluorosis in children aged 2-17 years living in the Lyubertsy district of the Moscow region have been presented in this article; the features of dental health of patients for each stage of occlusal developmenthave been established. Ключевые слова: Children; Dentofacial anomalies; Epidemiology; Fluorosis Заказать публикацию № 24 Номер заказа № 24 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 252) 3 место - продано (договор 253) 4 место - продано (договор 254) 5 место - продано (договор 255) Дополнительно по статье: Study Design: We collected experimental data concerning vertebrae sizes and performed an investigation of these data for different patient ages by methods of mathematical statistics. Purpose: The standard dimensions of vertebrae and intervertebral discs are of major importance for obtaining a comprehensive understanding of spine diseases and their successful treatment. The purpose is to study these sizes for children at the age of 9-14 years. Overview of Literature: Unfortunately, this issue is poorly presented in the corresponding literature. There are no systematic results. Only particular cases are presented. Materials and Methods: Experimental is based on the: results of X-ray investigations of children spines. Theoretical background is given by methods of mathematical statistics. Results: Systematic description of vertebrae sizes for children of age 9-14 is given. This specific age interval is the most common period of initiation of various pathological deformations of human spine. Conclusions: The acquired data both reflect the process of spine growth and can serve for building correct mathematical models of a healthful or diseased spine. Ключевые слова: Scoliosis; spine; vertebrae Заказать публикацию № 25 Номер заказа № 25 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 262) 3 место - продано (договор 263) 4 место - продано (договор 264) 5 место - продано (договор 265) Дополнительно по статье: Based on the data on the volume of food consumption data according to the results of the actual nutrition study among the adolescents at the age of 15-17 they calculated the intake of chemical contaminants with local food products and food raw materials. They determined the main food products for adolescents, where chemical contaminants occur most frequently: fruits and vegetables, meat, grain, fish, drinks and milk. They determined the systems most susceptible to the total nonspecific effects at 95%: circulatory, cardiovascular, central nervous and reproductive systems. By the influence of imported products on functional systems they revealed circulatory system and the cardiovascular system. With combined intake of pollutants by food intake, the total hazard index for non-carcinogenic effect development by domestic products (HI) made 9.36 (95%), for imported products HI made 3.1 (95%). Ключевые слова: Adolescent health; Chemical contaminants; Critical body systems; Non-carcinogenic risk; Regional exposure factors Заказать публикацию № 26 Номер заказа № 26 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 272) 3 место - продано (договор 273) 4 место - продано (договор 274) 5 место - продано (договор 275) Дополнительно по статье: The presented article deals with traumatic brain injury, which can cause convulsive seizures with the subsequent development of epilepsy, which is especially characteristic of young people. The problems of classification of posttraumatic epileptic seizures, development of their mechanisms, characteristics of diagnosis, as well as the stages of epileptogenesis leading to the development of traumatic epilepsy are considered. The variants of therapy are given in view of traumatic brain injury. It is noted that the use of electrical stimulation during individual phases of paroxysmal oscillations can be an effective method in preventing the development of homeostatic plasticity that is involved in the development of epileptogenesis. Ключевые слова: Classification; Epilepsy; Epileptogenesis; Traumatic brain injury Заказать публикацию № 27 Номер заказа № 27 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 282) 3 место - продано (договор 283) 4 место - продано (договор 284) 5 место - продано (договор 285) Дополнительно по статье: The age-related dynamics of the ECoG and convulsive epileptiform activity induced by intracortical microinjections of 4-aminopyridine were studied in three groups of Wistar rats at ages corresponding to childhood (P20-30), adolescence (P30?45), and adulthood (P90?P120). With aging, ECoG spectral power was found to increase during waking and ?sleep spindles? and to decrease during slow-wave sleep. Rats of adolescent age also showed statistically significant differences in measures of convulsive activity ? mean frequency of peak-wave complexes ? and the latent period of occurrence of epileptiform activity was greater than in childhood and adulthood. In addition, the total duration of epileptiform activity in rats of adolescent age was significantly lower than that in adult rats and rats at age P20?P30. The nervous system during the adolescent period may have specific protective mechanisms decreasing the intensity of convulsive activity (the ability to generate and propagate spike-wave activity), increasing resistance to epileptogen. Ключевые слова: 4-aminopyridine; ECoG; model of epilepsy; ontogeny; rats; spectral power Заказать публикацию № 28 Номер заказа № 28 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 292) 3 место - продано (договор 293) Дополнительно по статье: Problem and objective. The design of an individual educational trajectory with due account for the individual characteristics of cognitive processes is relevant in modern education. The objective of the study was to organize the students? cognitive activity in the conditions of the examination load, taking into account the psychophysiological profile as a criterion of health preservation. Materials and methods. The study involved 114 first-year female students aged 17-18 studying at the Faculty of Training Elementary School Teachers of the South Ural State Humanitarian and Pedagogical University in Chelyabinsk. The general sample was randomly differentiated into the main group (Group 1, n=61), for which the program Design of Students? Educational Trajectory Based on the Psychophysiological Profile was implemented, and the control group (Group 2, n=53), where traditional tests were performed. The diagnostics of the level of mental performance by the parameters of a simple visual-motor reaction was performed using a hardware-software package Biomysh(Biomouse) (Neurolab, Moscow). The situational and trait anxiety was assessed. The mathematical-statistical analysis was conducted with the use of Microsoft Excel and Statistica v. 7.0. Results. The population of students at the control stage of the study was characterized by an average level of mobility of nervous processes, an optimal speed of the nervous system, a moderate degree of trait and state anxiety. Upon the program completion, the students of the main group noted an increase in the average group indicator of the CNS reaction stability at high values of the reaction stability and reliability of the activity. No significant differences in the mean values of sensorimotor reactions of students in the studied groups have been identified. The indicators of state anxiety had a regular increase in mean values in both groups, but an increase in the mean value of the control group by an indicator of state anxiety was 3.5 times higher than that in the main group. Conclusion. Task scheduling with the use of the program Design of Students? Educational Trajectory Based on the Psychophysiological Profile makes it possible to improve academic performance with relatively constant rates of state and trait anxiety, and thus to ensure students? stable psychoemotional state as one of the conditions for health preservation. Ключевые слова: Educational trajectory; Examination stress; Mental performance; Sensorimotor reactions; Students Заказать публикацию № 29 Номер заказа № 29 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |
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2 место - продано (договор 302) 3 место - продано (договор 303) 4 место - продано (договор 304) 5 место - продано (договор 305) 6 место - продано (договор 306) Дополнительно по статье: Background and aims: The aim of this study is to investigate the relation between lipoprotein(a) [Lp(a)] and proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations, and their complex, in patients with potential familial hypercholesterolemia (FH), depending on apo(a) phenotype. Methods: The study included 205 patients with total cholesterol (TC) 7.5 mmol/L and/or low density lipoprotein cholesterol (LDL-C)4.9 mmol/L, 32 (15%) patients suffered from ischemic heart disease (IHD), 64 were taking statins. The diagnosis of FH was estimated according to the Dutch Lipid Clinics Network criteria. Lipid parameters, apoB-containing lipoprotein subfractions, Lp(a), PCSK9, Lp(a)-PCSK9 complex levels and apo(a) phenotype were determined. Depending on the apo(a) phenotype, all patients were divided into 2 groups: with high molecular weight (HMW) (n = 145) and low molecular weight (LMW) (n = 60) apo(a) phenotype. Results: The groups were comparable by all major clinical characteristics and biochemical parameters. In the whole group, PCSK9 concentration correlated with age, statins intake, Lp(a), TC and TG levels. Correlation between Lp(a) and PCSK9 levels was found only in the LMW apo(a) phenotype group independently of statins intake (r = 0.46, p 0.001). Associations between Lp(a)-PCSK9 complex and large subfractions of intermediate (r = 0.30) and low-density lipoproteins (r = 0.30, p 0.05 for both) were observed, with more significance in group 2 (r = 0.59, p 0.005 and r = 0.40, p 0.05, respectively). Conclusions: In patients with potential familial hypercholesterolemia, positive correlations between concentrations of Lp(a) and PCSK9, as well as of Lp(a)-PCSK9 plasma complex with large subfractions of intermediate and low-density lipoproteins (IDL-1 and LDL-C), were determined by the LMW apo(a) phenotype. Ключевые слова: Familial hypercholesterolemia; Lipoprotein subfractions; Lipoprotein(a); Proprotein convertase subtilisin/kexin type 9 Заказать публикацию № 30 Номер заказа № 30 Самый быстрый и простой способ заказать или задать вопрос, написать нам: Все контакты |